Use of levosimendan in different settings - Efficacy and safety




on Monday, May 28th  during  9:15 - 16:15 CEST (Central European Summer Time) LIVE from the ESC-HF congress

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11:15 - 12:15 Levosimendan and renal function: how to avoid kidney dysfunction in AHF?

11:15  Cardio-renal syndrome Kristjan Karason (Gothenburg, Sweden)

11:35  Therapeutic options Francesco Fedele (Rome, Italy)

11:55  Clinical practice Finn Gustafsson (Copenhagen, Denmark)

13:15 - 14:15 Levosimendan in HFrEF: on whom, when and how?

13:15  What is available? Zoltan Papp (Debrecen, Hungary)

13:35  Therapeutic needs Veli-Pekka Harjola (Helsinki, Finland)

13:55  Clinical practice John Parissis (Athens, Greece)

15:15 - 16:15 Repetitive use of levosimendan in advanced heart failure

15:15  Scientific evidence in the literature Carsten Tschöpe (Berlin, Germany)

15:35  Patient characteristics Gerhard Pölzl (Innsbruck, Austria)

15:55  Clinical practice and new data Fabrizio Oliva (Milan, Italy)


The use of inotropes for correcting hemodynamic dysfunction in patients with congestive heart failure has been described over many decades. However, negative or insufficient data has been collected on the effects of cardiac glycosides, cathecolamines, and phosphodiesthrase inhibitors on quality of life and survival. More recently, the calcium sensitizer and potassium channel opener levosimendan has been proposed as a safer inodilator. This series of webcasts focus on how to use safely and effectively levosimendan in acute and advanced heart failure.

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Kristjan Karason


Kristjan Karason (Gothenburg, Sweden)

Kristjan Karason is a specialist in internal medicine and cardiology, and senior lecturer in cardiology at the Gothenburg University. He is consultant in Cardiology and Transplantation at the Sahlgrenska University Hospital in Gothenburg. He is involved in various educational programs for the specialization schools and he is author of textbooks and over 100 scientific publications.



 Francesco Fedele
Francesco Fedele (Rome, Italy)

Fedele is Full Professor of Cardiology and Director of the Specialization School for Cardiologist of “La Sapienza” University of Rome, and Chief of Cardiology at the Department of Cardiovascular, Respiratory, Nephrology and Geriatrics Sciences at the “Policlinico Umberto I” Hospital. Fedele has been principal investigator in several International Clinical Trials and authored over 700 publications on national and international journals in research fields as cardiorespiratory pathophysiology, pathophysiology of ischemic heart disease, acute myocardial infarction, systemic and pulmonary hypertension, heart failure, echocardiography, and clinical pharmacological therapy.



Finn GustafssonFinn Gustafsson (Copenhagen, Denmark)

Finn Gustafsson, MD, PhD (born 1968) is a professor of cardiology at the University of Copenhagen and medical director of the advanced heart failure, transplantation and MCS program at Rigshospitalet in Copenhagen, Denmark. His clinical training in advanced heart failure took place in Denmark and Toronto, Canada. His research interests include several aspects of heart failure pathophysiology and management. He is an author of more than 200 peer reviewed articles and several book chapters. Dr. Gustafsson serves on the steering committee of several international clinical trials and registries within the field of advanced heart failure. He is an associate editor for Circulation: Heart Failure and on the editorial board of European Journal of Heart Failure. 



Zoltan Papp

Zoltan Papp (Debrecen, Hungary)

Zoltán Papp M.D. Ph.D. is an experimental cardiologist and chairman of the Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Hungary. He became full professor in 2010, and currently he also serves as the Vice-Dean for Scientific Affairs at the University of Debrecen. His main research interest relates to myocardial pathophysiology, cardiac contractility, cardiomyocyte physiology, ischemia-reperfusion injury, systolic and diastolic heart failure and myofilament targeted positive inotropic agents.




Veli-Pekka Harjola


Veli-Pekka Harjola (Helsinki, Finland)

Veli-Pekka Harjola is head of the Emergency Medicine Dvision in the Department of Emergency Services of the Hospital District of Helsinki and Uusimaa in Helsinki. He is also Associate Professor in the Faculty of medicine of the University of Helsinki. He is author of 120 PubMed-listed papers and currently active member of the Clinical section of the Heart Failure Association of the European Society of Cardiology.




John Parissis

John Parissis (Athens, Greece)

John Parissis is Associate Professor of Cardiology in the Second Department of Cardiology of Attikon General Hospital, University of Athens. He is a fellow of the European Society of Cardiology and member of the ESC Heart Failure and Acute Cardiac Care Associations. He is also an active member of the ESC committee for the national working groups or national societies on heart failure as well as member of the Task Force for Curriculum Heart Failure of the ESC Heart Failure Association. Dr Parissis has published 277 articles in Cardiology peer-review international journals  He is reviewer in 27 cardiology international journals including Lancet, Circulation, JACC, European Heart Journal.




Gerhards Pölzl


Gerhard Pölzl (Innsbruck, Austria)

Professor Gerhard Pölzl is Chief of the Heart Failure and Heart Transplant Program at the Medical University Innsbruck. His research is focused on clinical studies in advanced and chronic heart failure and on translational studies in cardiomyopathies. He has been Principal Investigator of the LevoRep clinical trial that tested the efficacy and safety of pulsed infusions of levosimendan in outpatients with advanced heart failure. He is currently P.I. of the clinical trial LEODOR, on repetitive use of levosimendan in advanced heart failure.



Carsten Tschöpe


Carsten Tschöpe (Berlin, Germany)

Univ. - Prof. Dr. med. Carsten Tschöpe is professor of Medicine and Cardiology and Vice Director of the Dept. of Cardiology, at the Campus Virchow Clinic (CVK) at the Charite, Berlin, guiding the Cardiomyopathy program.  He is the recipient of the 1st Research Prize of the Benjamin Franklin University Clinic and of the Arthus Weber Price of the german Society of cardiology.  He has been principal investigator in 8 clinical trails and and published over 300 scientific communications (with an h-index over 60) including some patents.



Fabrizio Oliva


Fabrizio Oliva (Milan, Italy)

Fabrizio Oliva is responsible of the Cardiac Critical Care units in Niguarda Hospital, Milan. He has had several duties and responsibilities in the national cardiology society ANMCO. He is in the editorial board of EJHF and revisor for several other Q1 cardiology journals. He published over 100 PubMed-listed scientific articles and is currently member of several working groups on drugs and therapies in cardiology.






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